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Apoptosis Activator 2

CAS No. 79183-19-0

Apoptosis Activator 2 ( —— )

Catalog No. M15971 CAS No. 79183-19-0

An apoptosis activator that strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Apoptosis Activator 2
  • Note
    Research use only, not for human use.
  • Brief Description
    An apoptosis activator that strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation.
  • Description
    An apoptosis activator that strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation; leads to the destruction of cells (Apaf-1 dependent) with IC50 of 4 uM; exert cytostatic and cytotoxic effects on a variety of cancer cell lines while having little or no activity against the normal cell lines tested.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Caspase-3
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    79183-19-0
  • Formula Weight
    306.14
  • Molecular Formula
    C15H9Cl2NO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 46 mg/mL
  • SMILES
    O=C1N(CC2=CC=C(Cl)C(Cl)=C2)C3=C(C=CC=C3)C1=O
  • Chemical Name
    1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nguyen JT, et al. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8.
2. Farivar TN, et al. N Am J Med Sci. 2012 Nov;4(11):582-5.
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